Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model
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چکیده
منابع مشابه
Lower energy radial shock wave therapy improves characteristics of hypertrophic scar in a rabbit ear model
The aim of the present study was to investigate the effects of radial extracorporeal shock wave therapy (rESWT) on scar characteristics and transforming growth factor (TGF)-β1/Smad signaling in order to explore a potential modality for the treatment of hypertrophic scars (HS). The HS model was generated in rabbit ears, then rabbits were randomly divided into 3 groups: Lower (L)-ESWT [treated wi...
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Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stab...
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This paper aimed to investigate the effect of tumstatin on hypertrophic scar in the rabbit model to explore a new treatment method for hypertrophic scar. An animal model of hypertrophic scar on the rabbit ears was established and was intervened with tumstatin via local injection. The rabbits were randomly assigned into tumstatin group, endostatin group, triamcinolone acetonide group and the sal...
متن کاملAnti-Vascular Endothelial Growth Factor (Bevacizumab) Therapy Reduces Hypertrophic Scar Formation in a Rabbit Ear Wounding Model
BACKGROUND Hypertrophic scarring is a pathological condition that occurs after trauma or surgery. Angiogenesis occurs more often with hypertrophic scarring than with normotrophic scarring. The regulation of angiogenesis is one of the key factors in hypertrophic scar management. Vascular endothelial growth factor (VEGF) is an essential factor in the angiogenetic response. This study investigated...
متن کاملRecombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1.
BACKGROUND Recombinant human endostatin (Endostar) has been widely used to suppress angiogenesis in carcinoma patients. Hypertrophic scar (HS) tissue, much like a carcinoma, is often associated with angiogenesis. However, there have been few studies conducted on the effects of Endostar on HS or its mechanism. OBJECTIVE This paper investigated the effects Endostar on the HS of rabbit ears and ...
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ژورنال
عنوان ژورنال: International Wound Journal
سال: 2021
ISSN: 1742-4801,1742-481X
DOI: 10.1111/iwj.13561